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The Indian Institute of Science Education & Research (IISER) Mohali was established in 2007 by the Government of India, through the Ministry of Human Resource Development (MHRD), to carry out research in frontier areas of science and to provide quality science education at the undergraduate and postgraduate level. The foundation stone was laid on 27th September 2006 by the Prime Minister of India. The first Director Prof.N Sathyamurthy joined on 18th June 2007. Classes for the first MS (Int) batch began on 16th August 2007. The transit campus was inaugurated on 13th November 2007.

The 5 yr MS (Int) program in Science at IISER Mohali admits students after 10+2. The course structure is interdisciplinary & research oriented in nature, with a focus on the basic sciences. The first two years of the program constitute a common core with courses from Physical Sciences, Chemical Sciences, Life Sciences, Mathematics & Computer Science, Humanities & Social Sciences, as well as Interdisciplinary courses. The MS degree is awarded in the subject in which the student opts to major in, after the core years. In the fifth year, the students will undertake a research project, and participate in state-of-the-art scientific research at IISER Mohalis research labs. The graduates are expected to take up science as a career, although the diverse skills gained will equip them to pursue high-profile careers in any field, including industry.